CTNNB1 and hepatocellular carcinoma: Furthermore, we noticed that, differently from colorectal cancers, which mainly show Thr41 and Ser45 mutations [36], HCV-related HCC shows a preference for CTNNB1 mutations from Asp32 to Ser37 residues [45, 47, 49, 59, 68, 70, 71] (Fig. 1).