Then, what’s the relationship among CML/RAGE, p38MAPK, reactive oxygen species (ROS), core-binding factor α1 (cbfα1, a key transcription factor inducing osteoblastic differentiation) and alkaline phosphatase (ALP, a specific marker of osteoblastic differentiation) in non-crosslink and non-fluorescent CML-induced calcification? This evidence concerns the gene AGER and chronic myelogenous leukemia, BCR-ABL1 positive.