Firstly, in the model of CML-accelerated VSMC calcification under high-lipid, apoptosis-coexisting conditions, anti-RAGE antibody, NADPH oxidase inhibitor DPI, p38MAPK inhibitor SB203580 and anti-cbfα1 antibody significantly inhibited ALP activity and intercellular calcium deposition, but the specific signal stream was unclear. The gene discussed is AGER; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.