Inhibiting the tyrosine 357 phosphorylation of YAPInhibiting interaction of YES1, YAP, and β-catenin complex independent of YES1 kinase activityInhibition of gut formation to a similar extent as the YAP or YES1 knockdownImpeding β-catenin-dependent proliferation of colon cancer cell lines. The gene discussed is YAP1; the disease is malignant colon neoplasm.