Further, to experimentally validate the contribution of RBPs in aggressiveness of GBM tumors, we selected Methyltransferase-like 1 (METLL1) and 2′-5′-Oligoadenylate Synthetase 1 (OAS1) which identified as aggressiveness related RBPs and were specifically upregulated in GBM tumors as compared to control samples. The gene discussed is METTL1; the disease is glioblastoma.