TNF and mantle cell lymphoma: As expected, TNFα (10 ng/ml) activated the NF-κB signaling pathway in three MCL cell lines, as indicated by the phosphorylation of IkBa, the degradation of IkBa and the induction of Mcl-1 and Bcl-XL in Rec-1 (Figure 6A), Jeko-1 (Figure 6B) and MAVER-1 (Figure 6C).