VWF and cancer: Further support for the hypothesis that VWF expression confers a significantly enhanced extravasation potential to cancer cells was provided by our in vivo mouse extravasation experiments, in which SAOS2-GFP expressing cells, treated with either VWFshRNA or NSshRNA, were injected into the tail vein of immunodeficient mice, and using an immunofluorescence imaging, the lungs of injected mice were analyzed for the presence of cancer cells 24 hours post injection.