Hepatic fibrosis (hazard ratio [HR], 5.706; 95% confidence interval [CI], 1.700–19.153; p = 0.005) and postoperative plasma GPC3 positivity (HR, 3.575; 95% CI, 1.239–10.314; p = 0.018) were significantly correlated with the risk of recurrence. The gene discussed is GPC3; the disease is Hepatic fibrosis.