BCL2 and cancer: The mechanism of drug resistance of Nrf2 was as follows: Nrf2 as a nuclear transcription factor transported into the nucleus and binding to the AREs sequence, activating the molecules downstream, such as antioxidant molecules, detoxification protein and inhibiting cell apoptosis (Bcl-2) and multidrug resistance drug associated protein (MRP), and then participated in the oxidative stress reaction to make cancer cells resistant to drugs [11–13].