We confirmed the high frequency of DS‐ALL among CRLF2‐r ALL (31%, 50/161) (DS status not available for 11 patients), with more DS‐ALL patients harboring the P2RY8‐CRLF2 fusion (P2RY8‐CRLF2, n = 41 vs. IGH‐CRLF2 n = 9, 35% vs. 20%, respectively, P = .087) (Supporting Information Table 4; Figure 1B). This evidence concerns the gene CRLF2 and acute lymphoblastic leukemia.