In our study, eight patients (72%) had one or more focal adhesion gene mutations; an incidence much higher than reported in other ALL subtypes (ETV6‐RUNX1, 12%23, Ph‐like non‐CRLF2‐r, 15%4, low hypodiploidy, 5%37, high hyperdiploidy, 9.8%38, KTM2A‐rearranged infant ALL, 4.5%36). Here, CRLF2 is linked to acute lymphoblastic leukemia.