In addition, a study in vitro from Díaz et al. [10] has shown that calcitriol inhibits significantly the tumor necrosis factor-α (TNF-α)-induced expression of interferon γ (IFN-γ) in cultured human trophoblasts, a process that conceivably reduces the likelihood of pregnancy-associated disorders such as miscarriage [2–3]. This evidence concerns the gene TNF and Miscarriage.