On the other hand, systemic inflammation (e.g., elevated c-reactive protein, elevated pro-inflammatory cytokines) has been documented in neonates with ECMO [30, 31], as well as in neonates with clinical sepsis [32] and studies have demonstrated that creatine is often elevated alongside choline in the setting of cerebral inflammation [25, 27]. The gene discussed is CRP; the disease is Sepsis.