To test this hypothesis, we established isogenic LKB1 stable knockdown NSCLC cells (H522 pLKO.1 and H522 LKB1 shRNA, H520 pLKO.1 and H520 LKB1 shRNA, H1650 pLKO.1 and H1650 LKB1 shRNA) using a lentivirus system. This evidence concerns the gene STK11 and non-small cell lung carcinoma.