However, we found no correlation between CTRP3 and inflammatory markers, but association between CTRP3 and CAD may be justified by potent anti-inflammatory effect of CTRP3 on inhibiting inflammatory signaling pathways, reducing secretion of inflammatory mediators [29,37] and its favorable role in systemic and chronic inflammation associated with insulin resistance and obesity [31], as well as, cardio-protective effects of CTRP3 [10]. Here, C1QTNF3 is linked to obesity due to melanocortin 4 receptor deficiency.