Due to the introduction regarding the roles of cytokines, the main aim of this study was to evaluate the serum levels of IL-6, IL-8, TGF-β and TNF-α in the patients with hypertension and CAD in comparison to individuals without hypertension and CAD who were under treatment with Aspirin, Clopidogrel, Atorvastatin, Metoprolol, Nitrates, Losartan, Captopril and Carvedilol. The gene discussed is CXCL8; the disease is hypertensive disorder.