We all know that basal hypocortisolemia, even if asymptomatic, should be treated with lifelong substitutive glucocorticoids, but cortisol supplementation should be reserved for only very stressful situations and, as such, is probably sufficient for patients with normal serum cortisol levels and corticotropin hyporesponsiveness. The gene discussed is POMC; the disease is adrenocortical insufficiency.