Incomplete suppression of plasma HIV-RNA—which results from ART drug resistance, lower baseline CD4+ T cell counts, and older age—is a significant predictor of immunological failure.[30] In our study, the rate of immunological failure was 32.5% and mostly occurred within 24 months of initial follow-up, which agrees with previous findings.[31] We suggest that being at WHO stage 4 is a more precise indicator of severe immunodeficiency and inflammation than baseline CD4+ T cell counts are. This evidence concerns the gene CD4 and immunodeficiency disease.