For instance, the +781C/T and −352A/T polymorphisms of IL-8 gene are related to cancer development,[10,11] while the 4073A/T polymorphism is associated with myocardial infarction.[12] Interestingly, increasing evidence has suggested that polymorphisms of inflammation-related genes may be associated with PE development, such as tumor necrosis factor-α, IL-10, and IL1A.[13,14] However, whether the genetic variations in IL-8 are associated with the risk of PE is poorly studied. This evidence concerns the gene CXCL8 and cancer.