This is in line with our earlier study that showed occurrence of malignant tumours after injection of iPS cells with p53R172H in mice.27 On the other hand, we also identified tumour suppressive miRNAs, like miR-218 that are upregulated in p53 mutant cells, and in the case of miR-218 downregulated in p53 wt cells. The gene discussed is TP53; the disease is neoplasm.