The same is true for miR-218, an miRNA that seems to acts as a tumour suppressor72, 73 and promotes stem cell differentiation.74, 75, 76 The tumour suppressive miR-708 and miR-126 on the other hand are upregulated during reprogramming in p53 wt cells and reduced in p53R172H cells. Here, TP53 is linked to neoplasm.