In primary tumors of 158 HCC patients, strong cytoplasmic OPN staining and weak E-cadherin expression was observed in most cases (Figure 6h, case 1); in other cases, the low cytoplasmic expression of OPN was accompanied by the membranous location of E-cadherin (Figure 6h, case 2). The gene discussed is CDH1; the disease is hepatocellular carcinoma.