SPP1 and breast adenocarcinoma: Lower abundance of miR-200s was observed in AKT1-knockout mammary adenocarcinomas than in wild-type or AKT2-knockout ones,22 and downregulation of AKT1 rather than AKT2 in IGF-1R-stimulated cells could induce EMT.23 We therefore detected AKT1 and AKT2 expression with altered expression of OPN.