VCAN and breast carcinoma: Versican was found to induce MET of breast cancer cells to favor metastatic development in the lungs.34 The potent miR-200s promoted MET by directly affecting the ZEB/E-cadherin axis, and high miR-200 expression was required for efficient colonization in secondary organs.5, 18, 19, 35 The overexpression of miR-429induced MET in metastatic ovarian cancer cells.36 Despite these findings, functional studies linking MET with metastatic colonization ability are relatively scarce.