In line with our observations, much of the literature showed that ST8SIA4 was implicated as a potential glycan cancer marker.30 Additionally, ST8SIA4 has also been shown to confer multidrug resistance in human chronic myeloid leukemia.31 These studies imply that upregulation of ST8SIA4 was breast cancer progression-related. The gene discussed is ST8SIA4; the disease is cancer.