Given the sound cellular evidence of HO-1 modulation on PCa cell adhesiveness and protrusive forces, we carried out an RNA-Seq analysis to compare gene expression profiles between PCa cells overexpressing HO-1 pharmacologically (hemin treatment) or genetically (transfected with pcDNA3HO-1) and their respective controls (Figure 6a). The gene discussed is HMOX1; the disease is posterior cortical atrophy.