HMOX1 and posterior cortical atrophy: Men with PCa display characteristically osteoblastic bone metastases, which are the main cause of morbidity and mortality of the disease.29 A previous report has shown HO-1 potentiality in modifying the bone microenvironment and subsequent PCa metastases.30 To explore the contribution of HO-1 in the interaction between PCa cells and osteoblasts, we used co-culture systems (PC3 and MC3T3).