Strikingly, when integrating the transcriptome under HO-1 modulation with the HO-1 interactome, a framework of four main molecular pathways arose as the foundation for the regulation of the tumor cell protrusive forces: ANXA2/HMGA1/POU3F1; NFRSF13/GSN; TMOD3/RAI14/VWF; PLAT/PLAU. This evidence concerns the gene HMGA1 and neoplasm.