TES, a scaffold protein that participates in the reorganization of the actin cytoskeleton,33 is known for being a tumor suppressor in PCa.34 MKLN1, a nucleocytoplasmic mediator of cellular morphology and adhesiveness,35 exhibits similar sub-cellular dynamics to HO-1, relocating from the cell membrane toward the cell nuclei under hemin treatment.13 This evidence concerns the gene TES and neoplasm.