BCL2 and B-cell non-Hodgkin lymphoma: The B-cell lymphoma-2 (Bcl-2) gene was originally discovered by Yoshide Tsujimoto at the chromosomal breakpoint translocation when chromosome 18 translocated to chromosome 14 in B-cell lymphomas [14], both antiapoptosis members such as BCL-2, BCL-XL, BCL-W, A1, MCL1, and proapoptosis members such as BAK and BAX were discovered [15].