Over the past 20 years, numerous other ALK fusions have been identified, which form functional chimeric proteins in human cancers such as ALCL, diffuse large B-cell lymphoma, and inflammatory myofibroblastic tumors, as well as esophageal squamous cell, breast , colon, thyroid, renal cell, and non-small cell lung cancer (NSCLC) [2]. This evidence concerns the gene ALK and anaplastic large cell lymphoma.