Although tumor angiogenesis was significantly reduced in tumor regions of mice injected with ganglioside-depleted tumor cells by double-knock out of Siat9 and Galgt1, compared to those of mice injected with tumor cells, the production of VEGF and other angiogenic factors, such as cytokines and growth factors, in ganglioside-depleted tumor cells was not changed, compared to tumor cells [8]. Here, ST3GAL5 is linked to neoplasm.