KRAS and adenocarcinoma: Compared to tamoxifen/cerulein-treated Elas-CreER;Kras+/LSLG12D mice fed a normal diet, tamoxifen/cerulein-treated Elas-CreER;Kras+/LSLG12D mice fed a high fructose diet for 6 weeks exhibited more high-grade PanIN lesions (as judged by the expression of Mucin 5AC) and adenocarcinomas (as judged by the expression of CA19-9 tumor antigen) (Figure 1C).