KRAS and pancreatic neoplasm: To comprehensively characterize neoplastic lesions generated in tamoxifen/cerulein-treated Elas-CreER;Kras+/LSLG12D mice fed either a normal diet or high fructose diet, we conducted immunohistochemical staining to examine the expression of acinar-cell markers-amylase (AMY) and GLUT5, as well as markers expressed in drug-resistant PDAC cells and/or pancreatic cancer stem cells, including ABCG2, CD44, and CD133 [26–28] (Figure 1D, 1E).