Evidence from recent work suggests that pancreatic cancer comprises several subsets of CSCs, including ESA+CD24+CD44+ cells, CD133+CXCR4+ cells, and c-Met+ subset cells, which are defined by their self-renewal ability, tumorigenicity, and metastatic ability [27, 28, 34, 35]. This evidence concerns the gene CXCR4 and familial pancreatic carcinoma.