AREG and neoplasm: Of the EGFR ligands, the expression of amphiregulin at a cut-off value of > 10% tumour cells (P = 0.013), EGF (>50%) (P = 0.045), and co-expression of epigen/BTC (P = 0.032) were significantly associated with an increased disease progression in this study (Table 3), while BTC expression at cut-off value of > 5% was associated with decreased disease progression (P = 0.006).