Several oncogenes, like c-Myc, are able to enhance the production of ribosomal components, by the stimulation of all the three RNA Polymerases [6–9], while tumor suppressors like p14 ARF or p53, are able to bind and inhibit the activity of several transcription factors like SL1 and UBF, needed for Polymerase I transcription, leading to ribosome biogenesis inhibition [10, 11]. The gene discussed is CDKN2A; the disease is neoplasm.