Different from BTZ, the most important working mechanisms of IMiDs (such as, LEN and Thal) include T-cell co-stimulatory, suppression of Tregs, and disruption of myeloma cell -BMSC interaction [14]; Thus, a relative high dose (10 μm) was used for both LEN and Thal in our model [1, 33]. This evidence concerns the gene CASC3 and plasma cell myeloma.