CXCL12 and plasma cell myeloma: These interactions include SDF-1-induced MIC-BMSC positive feedback loops, the myeloma lineage process from MIC to MM, TGFβ-induced immune suppression, and CTL-mediated target cell lysis etc. At the tissue level, intracellular signaling pathways are triggered by the local SDF-1 or TGFβ via the interfaces of cell agents, and the changes in the cells’ fate and behaviors in turn modulate the environment for cell growth.