We also established an agent-based model using the Markov Chain Monte Carlo approach to simulate the effects of SDF-1-induced chemo-physical communications among MICs and BMSCs on myeloma cell growth and examine if the biophysical properties of myeloma niches are druggable with two representative drugs: AMD3100, and Bortezomib (BTZ) [11]. Here, CXCL12 is linked to plasma cell myeloma.