Considering the special inhibiting effects to SDF-1/CXCR4 signaling pathway in MM [1], Thal indirectly inhibits the proliferation of myeloma cells by regulating the SDF-1-trigged stiffness of BMSC and further decreases the secretion of TGFβ from BMSC. The gene discussed is CXCL12; the disease is plasma cell myeloma.