Interaction of myeloma cells with bone marrow stromal cells (BMSCs) via some key factors (SDF-1, TGFβ, IFNγ, IL6, and TNFα, etc.), induces pleiotropic anti-apoptotic mechanisms, thereby rendering multiple myeloma cells resistant to established therapeutic regimens [4, 5]. The gene discussed is TNF; the disease is plasma cell myeloma.