NFE2L2 and acute myeloid leukemia: In this work, we used an ARE-luciferase reporter approach to screen a series of pyrazolyl hydroxamic acid derivatives and identified a novel compound, 1-(4-(tert-Butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H pyrazole-5-carboxamide (4f), that inhibited Nrf2 activity, for an anti-growth effect on AML cells.