BAX and acute myeloid leukemia: Bax protein level was increased and that of Bcl-2 protein level and ratio of Bcl-2/Bax were decreased when THP-1 cells were exposed to 4f at 5 and 10 μM for 48 h (Figure 7A–7C), with similar effects in the two other AML cell types (Figure 7D–7I).