ALDH5A1 and glioblastoma: In addition, the analysis of published transcriptome dataset of early-passage (P3) GBM cells either devoid of or endowed with self-renewing and tumor-initiating properties [32], revealed downregulated ALDH5A1, and conversely up-regulated AKR7A2 expression in non-tumorigenic cells compared to tumorigenic cells (Fig. 3b).