SSADH downregulation by siRNA targeting of ALDH5A1 mRNA (Fig. 1f) caused accumulation of GHB not only in stem-like cells of adult GBM but also in stem-like cells of infant DIPG, a form of high-grade glioma with a poor prognosis [58] (Fig. 1g). This evidence concerns the gene ALDH5A1 and diffuse intrinsic pontine glioma.