The network inferred for the NRF2 pathway is involved in pathways which are associated with key events indicated in AOPs for fibrosis (TGFB signalling, apoptosis) or cholestasis (oxidative stress, apoptosis) (Vinken 2015), or are related to liver cancer (p53 signalling (Hanahan and Weinberg 2011), SLC-mediated transmembrane transport (El-Gebali et al. 2013)). This evidence concerns the gene CCL21 and cholestasis.