The network inferred for the NRF2 pathway is involved in pathways which are associated with key events indicated in AOPs for fibrosis (TGFB signalling, apoptosis) or cholestasis (oxidative stress, apoptosis) (Vinken 2015), or are related to liver cancer (p53 signalling (Hanahan and Weinberg 2011), SLC-mediated transmembrane transport (El-Gebali et al. 2013)). Here, TGFB1 is linked to liver cancer.