COMT and major depressive disorder: In adults, COMT has been associated with prefrontal functioning and executive control in schizophrenia (Ehlis, Reif, Herrmann, Lesch, & Fallgatter, 2007), social cognition in bipolar disorder (Soeiro‐de‐Souza et al., 2012), as well as risk for obsessive‐compulsive disorder (Azzam & Mathews, 2003) and early onset major depressive disorder (Massat et al., 2005).