An overexpression of sFlt-1, an endogenous anti-angiogenic protein that is made by the placenta and acts by neutralizing the proangiogenic proteins VEGF and PlGF, has been shown to produce proteinuria, hypertension and glomerular endotheliosis in pregnant rats, a phenotype consistent with pre-eclampsia. The gene discussed is VEGFA; the disease is Hypertension.