In patients with elevated PSA (>3 ng/ml), low percent-free PSA or suspicious DRE, the 4k-panel of kallikrein markers improved discrimination over age and PSA for high-grade cancer (GS ≥7; AUC = 0.77 vs 0.720; p = 0.002), reducing the number of biopsies by 236 per 1000 to detect 195 of 208 high-grade cancers [63]. Here, KLK4 is linked to cancer.