It is commercially available as a diagnostic test that quantitatively detects PCA3 RNA expression in the urine and prostatic fluid after prostatic massage with a score higher than 35 in the urine correlating with an average sensitivity and specificity of 66 and 76%, respectively, for the diagnosis of PCa (compared with a sensitivity of 65% and specificity of 47% for PSA alone) [35]. This evidence concerns the gene KLK3 and posterior cortical atrophy.