Furthermore, STAT3 knockdown inhibits sphere formation derived from human PCa cells [43] The crucial role of STAT3 in PCSCs may be explained by its role in the IL-6 signaling, as sustained by the notion that soluble IL-6 receptor fusion protein can significantly reduce CSC number and xenograft tumor growth in in vivo PCa models [43]. The gene discussed is IL6; the disease is posterior cortical atrophy.