We first developed water-soluble polymeric ZnPP micelles, in other wrods, pegylated ZnPP and styrene maleic acid copolymer micelles encapsulating ZnPP, as a potential anticancer agent by targeting heme oxygenase-1 to decrease the antioxidant defense activity of tumor cells and thus induce cell death (apoptosis) caused by oxystress produced by infiltrated macrophages and leukocytes [18–20]. Here, HMOX1 is linked to neoplasm.