Evidence implicating PD-L1 in immune evasion among common B-cell NHL, in conjunction with the high response rates, as high as 87%, observed in relapsed or refractory Hodgkin’s lymphoma with PD-1 CPB [9–11], provides a strong rationale for this approach in B-cell NHL. The gene discussed is CD274; the disease is B-cell non-Hodgkin lymphoma.