CTLA4 and neoplasm: While late intervention of anti-PD-1 and anti-CTLA-4 on large, established CT26 colon cancer and 4 T1 breast cancer did not have any therapeutic efficacy, supplementing the combination therapy with 5-azacytidine and etinostat to inhibit MDSCs, sensitized tumors to NCR blockade leading to tumor reduction [62].