For this type of cancer stem cells, the following ontological paired trigger molecules and TF are detected: extracellular activator/stabilizer IGF/IGFBP5 as a marker of the extracellular secreted growth factor [70] and the transcription factor FOSL1 [71], activating the specific gene platform and, in particular, triggering the synthesis of MMP9, which leads to reorganization of the extracellular matrix. Here, IGFBP5 is linked to cancer.