Our data showed that 13 out of 18 candidates that included four genes (RASSF1A, RUNX3, APC, and COX2) and six miRNAs (miR-589, miR-10b, miR-203, miR-124-3, miR-647 and miR-129-2), were hyper-methylated in more than50% of tumor samples compared to the adjacent normal tissues. Here, RUNX3 is linked to neoplasm.