AFP and Cirrhosis: Based on the univariate analysis, the significant prognostic factors for survival included cirrhosis (P = 0.0086), the histologic grade (P = 0.0382), AFP (P < 0.0001), the pathological stage (P = 0.0054), the clinical stage (P < 0.0001), vascular invasion (P < 0.0001) and the MPM-BC (P = 0.0052) (Table 2).