Additional proteins participating in the iron uptake and non-transferrin bound iron uptake (NTBI) such as natural resistance associated protein (NRAMP2) coded by the solute carrier family 11 member 2 (SLC11A2) gene and zinc importer protein 14 (ZIP14) encoded by the solute carrier family 39 member 14 (SLC39A14) play an important role in the cellular and systemic iron metabolism together with the hemochromatosis (HFE) gene and protein which is connected with excessive iron loading [3, 15–20]. The gene discussed is SLC11A2; the disease is hemochromatosis type 1.