Vaccination of C57BL/6 mice induced a strong proinflammatory response in the blood, with a median of 4.8% CD8+ IFN-γ+ cells (Fig. 1A), and provided a significant delay in the time to 1% parasitemia while also sterilely protecting 3/8 mice (P < 0.0001 by the log-rank [Mantel-Cox] test) (Fig. 1B). This evidence concerns the gene CD8A and parasitic infectious disease.