CALCA and pancreatic neoplasm: ROCK2 immunostaining of normal pancreata as well as pancreatic tumors from LSL‐KrasG12D; Pdx1‐Cre (KC) or LSL‐KrasG12D; LSL‐p53R172H; Pdx1‐Cre (KPC) mice revealed weak ROCK2 expression in healthy normal tissue from wild‐type mice, with progressive elevation in developing lesions of acinar‐ductal metaplasia (ADM), pancreatic intraepithelial neoplasia (PanIN) stages 1–3, and highest expression in PDAC tumors (Fig 1F and G).