To conditionally activate ROCK2:ER in Pdx1‐expressing KrasG12D/p53R172H pancreatic tumor cells (Appendix Figs S2 and S3), tamoxifen citrate or vehicle control was administered to RKPC cohorts for 9 weeks, starting at 10 weeks of age when KPC mice have typically progressed to the PanIN stage (Fig 1F) (Morton et al, 2010). This evidence concerns the gene ROCK2 and pancreatic neoplasm.