PLK1 and neoplasm: The tumor cells from mice treated with A10-liposome-PLK1 CRISPR/Cas9 chimeras, in contrast to those from mice treated with PBS, free CRISPR/Cas9, or A10-liposome-scrambled CRISPR/Cas9 chimeras, were vacuolated, extensively granulated, and showed evidence of necrosis (Figure 6F).