We found that high expression of PD-L1 on cancer cell membranes correlated with lymph node metastasis and strongly correlated with poor-differentiation, high expression of PD-1 on cell membranes of TILs correlated with well-differentiation and strongly correlated with advanced T stage, high PD-1 expression was associated with a significantly superior OS and was an independent prognostic factor. This evidence concerns the gene CD274 and metastatic malignant neoplasm in the lymph nodes.