In vitro repression of BARD1β caused SNP genotype-specific inhibition of cell proliferation in neuroblastoma cells, and overexpression of BARD1β, but not FL BARD1, led to the transformation of non-malignant fibroblasts, suggesting that BARD1β is an oncogenic driver of high-risk neuroblastoma [32]. This evidence concerns the gene FLT3LG and neuroblastoma.