AKT2 and cancer: By contrast, large-scale analyses of EMT phenotypes in CTCs, using a combination of multiple epithelial and mesenchymal markers such as EpCAM, CK8/18/19, VIM, TWIST1, AKT2, and SNAI1, could provide more convincing evidence of the clinical value of different CTC phenotypes, and expand our understanding of their contribution to the development and progression of cancer.