PIK3CA and cancer: Tumor suppressor APC is lost in 85% of CRCs, leading to β-catenin stabilization, activation of Wnt targets such as c-Myc (Myc) and cyclin D1 and cancer initiation, which cooperates with hyperactivated RAS/RAF/ERK, and PI3K/AKT/mTOR signaling in cancer progression [2, 3].