Our recent work demonstrates that therapeutic effects of both allosteric and ATP-competitive mTOR inhibitors (mTORi) are mediated through induction of endoplasmic reticulum (ER stress) and apoptosis upon acute inhibition of eiF4E in colon cancer cells in culture and in mice, not the reversible growth suppression or inhibition on S6K induced by much lower doses [15]. This evidence concerns the gene MTOR and malignant colon neoplasm.