In our previous study, we demonstrated that panobinostat (pan-HDACI) suppresses the expression of three critical DDR proteins, BRCA1, CHK1, and RAD51, leading to enhancement of DNA DSBs, abrogation of cell cycle checkpoints, and enhanced induction of apoptosis by ara-C or DNR in AML cells [14]. Here, BRCA1 is linked to acute myeloid leukemia.