Our finding that FAF1 is suppressed by H. pylori-activated NF-κB signaling in gastric carcinogenesis, coupled with previous reports that FAF1 inhibits NF-κB activity by interfering with nuclear translocation of p65 [21] and IKKβ [22], suggests a new set of interactions that can be analyzed more deeply to gain more insights into how gastric cancer progresses. The gene discussed is FAF1; the disease is gastric cancer.