To explore which MAPK leads to CYP2J2 transcription via Hcy in HCC, we incubated LO2 cells with 20 μM of specific inhibitors for ERK1/2 (PD98059 and U0126), JNK (SP600125), or p38 (SB203580) for 1 h before stimulation with Hcy. The gene discussed is MAPK8; the disease is hepatocellular carcinoma.