CRP and folate deficiency: As compared with the control diet, the AIN-93G diet supplemented with methionine (M+) significantly increased serum levels of Hcy, total bile acids, total cholesterol, low-density lipoprotein and C-reactive protein (CRP); as compared with the M+ diets, folate deficiency (M+F- diet) or enrichment (M+F+ diet) significantly increased or decreased serum Hcy and CRP levels, respectively (Supplementary Table 3).